Chemistry Heterocyclic Building Blocks Pyridines 3-fluoro-2-methylpyridine
Ambeed provide 15 derivatives of 3-fluoro-2-methylpyridine.
These compounds have the same murcko framework: 3-fluoro-2-methylpyridineSubstitution Reactions: The fluorine atom in the 3-position can undergo substitution reactions with various nucleophiles or electrophiles, depending on reaction conditions. For instance, nucleophilic substitution reactions might replace the fluorine with another nucleophile such as a hydroxide ion, while electrophilic substitution reactions might replace it with an electrophile such as a halogenating agent.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases like butyllithium or organometallic compounds like Grignard reagents. This can lead to the formation of organometallic complexes which can further react in various ways.
Oxidation Reactions: The methyl group adjacent to the fluorine atom could undergo oxidation under appropriate conditions, resulting in the formation of a carboxylic acid, ketone, or other oxidized products.
Reduction Reactions: Conversely, the fluorine-substituted pyridine can undergo reduction reactions, potentially reducing the fluorine to a lower oxidation state or reducing functional groups elsewhere in the molecule.
Ring-closure Reactions: The presence of the fluorine atom and the methyl group could facilitate ring-closure reactions under certain conditions, leading to the formation of heterocyclic compounds.
Functional Group Transformations: The molecule could undergo various functional group transformations depending on the reagents and conditions present. For example, it could undergo acylation, alkylation, or other common organic transformations.
Cross-coupling Reactions: The fluorine atom could serve as a handle for cross-coupling reactions, where it could be replaced with various substituents via palladium-catalyzed coupling reactions such as Suzuki, Stille, or Heck coupling.
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(5-Fluoro-6-methylpyridin-3-yl)boronic acid
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5-Fluoro-6-methylpyridine-2-carboxylic acid
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3-Fluoro-5-(hydroxymethyl)-2-methylpyridine