Chemistry Heterocyclic Building Blocks Pyridines 3-fluoropicolinonitrile
Ambeed provide 5 derivatives of 3-fluoropicolinonitrile.
These compounds have the same murcko framework: 3-fluoropicolinonitrileSubstitution Reactions: The fluorine atom in 3FPN can undergo substitution reactions, where it can be replaced by other functional groups or nucleophiles. For instance, nucleophilic aromatic substitution reactions can occur, leading to the substitution of the fluorine atom with a nucleophile.
Addition Reactions: The cyano group (-CN) in 3FPN is susceptible to addition reactions, where molecules add across the carbon-nitrogen triple bond. This can lead to the formation of various derivatives depending on the reagents and conditions.
Reduction Reactions: The cyano group (-CN) can undergo reduction reactions to form primary amines or other reduced derivatives. This can be achieved using reducing agents such as hydrogen gas (H2) with a suitable catalyst or using other reagents like metal hydrides.
Metalation Reactions: The pyridine ring in 3FPN can undergo metalation reactions, where a metal atom is inserted into the aromatic ring. This can serve as a useful synthetic step in further functionalizing the molecule.
Coupling Reactions: 3FPN can participate in coupling reactions, such as Suzuki coupling or Heck coupling, where it can be coupled with other organic molecules under suitable conditions to form new carbon-carbon or carbon-heteroatom bonds.
Functional Group Interconversion: Various functional groups present in 3FPN can be interconverted using appropriate reagents and conditions. For example, the cyano group (-CN) can be converted into a primary amine, carboxylic acid, or other functional groups through suitable synthetic transformations.
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3-Fluoro-5-(trifluoromethyl)picolinonitrile
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(6-Cyano-5-fluoropyridin-3-yl)boronic acid