Chemistry Heterocyclic Building Blocks Pyridines 3-fluoropyridin-4-amine
Ambeed provide 4 derivatives of 3-fluoropyridin-4-amine.
These compounds have the same murcko framework: 3-fluoropyridin-4-amineNucleophilic substitution reactions: The amino group can act as a nucleophile in substitution reactions. For instance, it can undergo substitution with electrophiles such as alkyl halides or acyl halides to form N-alkyl or N-acyl derivatives, respectively.
Amination reactions: The amino group can be further functionalized via amination reactions to introduce additional substituents. For example, it can undergo reductive amination with carbonyl compounds or amine coupling reactions with a variety of electrophiles.
Fluorination reactions: The fluorine atom can participate in various fluorination reactions to introduce fluorine-containing functional groups. For example, it can undergo nucleophilic fluorination or electrophilic fluorination reactions.
Cross-coupling reactions: The amino group can participate in cross-coupling reactions such as Suzuki-Miyaura, Heck, or Sonogashira reactions to form biaryl or aryl-alkene derivatives.
Oxidation reactions: Both the amino group and the fluorine atom are susceptible to oxidation reactions under appropriate conditions. For instance, the amino group can be oxidized to form nitro or oxime derivatives, while the fluorine atom can undergo various fluorine oxidation states.
Reduction reactions: Conversely, both functional groups can also undergo reduction reactions. For example, the amino group can be reduced to form an amine derivative, while the fluorine atom can undergo reductive defluorination to form a hydrogen atom.
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2-(Difluoromethyl)-5-fluoropyridin-4-amine hydrochloride