Chemistry Heterocyclic Building Blocks Pyridines 3-iodopyridin-2-amine
Ambeed provide 12 derivatives of 3-iodopyridin-2-amine.
These compounds have the same murcko framework: 3-iodopyridin-2-amineSubstitution Reactions: Due to the presence of the iodine atom, nucleophilic substitution reactions can occur. For instance, nucleophiles like amines or thiols can substitute the iodine, leading to the formation of new compounds.
Cross-Coupling Reactions: 3-iodopyridin-2-amine can undergo cross-coupling reactions with various organometallic reagents (e.g., Grignard reagents, organozinc compounds) to form biaryl compounds or heteroaryl compounds.
Reductive Amination: The amino group in 3-iodopyridin-2-amine can undergo reductive amination reactions with suitable carbonyl compounds (such as aldehydes or ketones) in the presence of reducing agents to form secondary amines.
Metal-Catalyzed C-H Activation: The pyridine ring in 3-iodopyridin-2-amine can undergo metal-catalyzed C-H activation reactions, enabling the introduction of various functional groups at specific positions of the pyridine ring.
Cyclization Reactions: 3-iodopyridin-2-amine can participate in cyclization reactions under suitable conditions, leading to the formation of heterocyclic compounds.
Oxidation Reactions: The amino group in 3-iodopyridin-2-amine can undergo oxidation to form various functional groups, such as nitro groups or imines, depending on the reaction conditions.
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3-Iodo-5-(trifluoromethyl)pyridin-2-amine