Chemistry Heterocyclic Building Blocks Pyridines 3-iodopyridin-2-ol
Ambeed provide 4 derivatives of 3-iodopyridin-2-ol.
These compounds have the same murcko framework: 3-iodopyridin-2-olSubstitution Reactions: The iodine atom in 3-iodopyridin-2-ol can undergo substitution reactions where it is replaced by other nucleophiles. For example, it can react with a strong nucleophile to form a substituted pyridine derivative.
Oxidation Reactions: The hydroxyl group in 3-iodopyridin-2-ol can undergo oxidation reactions under appropriate conditions. For instance, it can be oxidized to form a ketone or a carboxylic acid, depending on the reaction conditions and reagents used.
Metal-Mediated Reactions: 3-Iodopyridin-2-ol can participate in metal-mediated reactions, where the iodine atom acts as a leaving group. This can lead to various transformations, such as coupling reactions in organometallic chemistry.
Cross-Coupling Reactions: It can undergo cross-coupling reactions with suitable partners, leading to the formation of biaryl compounds or other functionalized derivatives.
Nucleophilic Addition Reactions: The pyridine ring in 3-iodopyridin-2-ol can undergo nucleophilic addition reactions at the C-2 position, particularly with strong nucleophiles.
Reduction Reactions: The iodine atom or the hydroxyl group can be selectively reduced under appropriate reaction conditions, leading to the formation of corresponding products.
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