Chemistry Heterocyclic Building Blocks Pyridines 3-methoxypyridin-2-amine
Ambeed provide 5 derivatives of 3-methoxypyridin-2-amine.
These compounds have the same murcko framework: 3-methoxypyridin-2-amineAcylation: The amine group can undergo acylation reactions, forming amides or imides when reacted with acyl chlorides or anhydrides.
Alkylation and Arylation: The amine group can be alkylated or arylated by reaction with alkyl or aryl halides under appropriate conditions.
N-Acylation: The amine nitrogen can undergo N-acylation reactions with acid chlorides or anhydrides to form N-acyl derivatives.
Substitution Reactions: The pyridine ring can undergo substitution reactions such as electrophilic aromatic substitution (e.g., nitration, halogenation) or nucleophilic aromatic substitution.
Condensation Reactions: It can undergo condensation reactions with carbonyl compounds, such as aldehydes or ketones, to form Schiff bases or imines.
Reduction: The nitro group obtained from nitration can be reduced to an amine group under appropriate conditions.
Oxidation: The amine group can be oxidized to a nitro group or other oxidized forms under strong oxidizing conditions.
Cyclization Reactions: Depending on the reaction conditions and reagents used, it can undergo cyclization reactions to form heterocyclic compounds.
Metal Complexation: It can form complexes with various metal ions, leading to changes in its chemical properties and reactivity.
Diazo Coupling: It can undergo diazo coupling reactions with diazonium salts to form azo compounds.
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3-Methoxy-4-(trifluoromethyl)pyridin-2-amine
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4-(Difluoromethyl)-3-methoxypyridin-2-amine