Chemistry Heterocyclic Building Blocks Pyridines 3-nitropyridin-2-ol
Ambeed provide 11 derivatives of 3-nitropyridin-2-ol.
These compounds have the same murcko framework: 3-nitropyridin-2-olNitration: Further nitration of the pyridine ring can occur, especially under harsh conditions, leading to the introduction of additional nitro groups.
Reduction: The nitro group can undergo reduction to yield the corresponding amine derivative, typically using reducing agents such as iron and hydrochloric acid (Fe/HCl), or other metal catalysts.
Esterification: The hydroxyl group can undergo esterification reactions with carboxylic acids or acyl chlorides to yield ester derivatives.
Acylation: The hydroxyl group can undergo acylation reactions with acyl chlorides or acid anhydrides to yield ester derivatives.
Etherification: The hydroxyl group can undergo etherification reactions with alkyl halides or alkyl sulfonates to yield ether derivatives.
Substitution Reactions: Both the hydroxyl and nitro groups can undergo substitution reactions, where one functional group is replaced by another. For instance, the hydroxyl group can be replaced by halogens or other nucleophiles.
Oxidation: The alcohol functionality can be oxidized to form aldehyde or carboxylic acid derivatives, depending on the oxidizing conditions.
Condensation Reactions: The hydroxyl group can participate in condensation reactions, such as the formation of Schiff bases with carbonyl compounds.
Ring Closure Reactions: The hydroxyl and nitro groups can participate in ring-closure reactions under appropriate conditions, leading to the formation of fused or spiro cyclic compounds.
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5-Bromo-2-hydroxy-6-methyl-3-nitropyridine
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3-Nitro-5-(trifluoromethyl)pyridin-2-ol