Chemistry Heterocyclic Building Blocks Imidazolidines 3-phenyl-2-thioxoimidazolidin-4-one
Ambeed provide 6 derivatives of 3-phenyl-2-thioxoimidazolidin-4-one.
These compounds have the same murcko framework: 3-phenyl-2-thioxoimidazolidin-4-one.
Nucleophilic Substitution: The thioxo group is susceptible to nucleophilic attack, and the compound can react with nucleophiles to form various products.
Acylation: The carbonyl group (C=O) can undergo acylation reactions with acylating agents (e.g., acyl halides or anhydrides) to form amides or other derivatives.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: The sulfur atom can be oxidized to form sulfoxides or sulfones.
Cyclization: Depending on the reaction conditions, the compound may undergo intramolecular cyclization reactions, forming different cyclic structures.
Reaction with Grignard Reagents: The compound can react with Grignard reagents to form new carbon-carbon bonds.
Halogenation: The phenyl group can be halogenated (e.g., chlorination or bromination) under appropriate conditions.
Substitution Reactions: The compound can undergo various substitution reactions, such as nucleophilic aromatic substitution or electrophilic aromatic substitution.
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5-Methyl-3-phenyl-2-thioxoimidazolidin-4-one
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3-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)propanoic acid