3-phenylmorpholine-Morpholines| Ambeed

Chemistry Heterocyclic Building Blocks Morpholines 3-phenylmorpholine

3-phenylmorpholine

Ambeed provide 8 derivatives of 3-phenylmorpholine.

These compounds have the same murcko framework: 3-phenylmorpholine.

Acid-Base Reactions: Like morpholine, 3-phenylmorpholine can act as a weak base. It can react with acids to form salts. For example, it can react with hydrochloric acid (HCl) to form the 3-phenylmorpholinium chloride salt.
Substitution Reactions: The phenyl group on the morpholine can undergo electrophilic aromatic substitution reactions. For instance, it can undergo halogenation (e.g., bromination or chlorination) when treated with appropriate reagents.
Nucleophilic Substitution: The nitrogen atom in the morpholine ring can act as a nucleophile in certain reactions. It can undergo nucleophilic substitution reactions with electrophiles. For instance, it can react with alkyl halides to form N-alkylated products.
Ring Opening Reactions: The morpholine ring can undergo ring-opening reactions with various electrophiles. This can result in the formation of open-chain products, which can then undergo further reactions.
Oxidation Reactions: 3-phenylmorpholine can undergo oxidation reactions under appropriate conditions. For example, it can be oxidized to produce corresponding N-oxide compounds.
Reduction Reactions: Conversely, it can also be reduced under suitable conditions, which may lead to the formation of dihydro or tetrahydro derivatives.
Acylation and Alkylation Reactions: 3-phenylmorpholine can react with acylating agents (e.g., acyl chlorides) or alkylating agents (e.g., alkyl halides) to introduce acyl or alkyl groups onto the nitrogen atom.