Chemistry Heterocyclic Building Blocks Piperidines 3-phenylpiperidine
N-Formylation: Treatment with formic acid and a dehydrating agent can lead to N-formylation of the piperidine ring.
Reduction: The phenyl group can be reduced using reagents like lithium aluminum hydride (LiAlH4) to form a secondary amine.
Nucleophilic Substitution: If there are suitable leaving groups on the molecule, it can undergo nucleophilic substitution reactions. For example, reaction with halogenated compounds can lead to substitution on the piperidine ring.
Ring Opening: In the presence of strong acids or bases, the piperidine ring can undergo ring-opening reactions to form open-chain compounds.
Oxidation: Depending on the reaction conditions, the compound can undergo oxidation reactions. For example, the phenyl group can be oxidized to a phenyl ketone.
Cyclization Reactions: 3-phenylpiperidine can participate in intramolecular cyclization reactions to form different types of cyclic compounds.
Heterocycle Formation: In some reactions, it can participate in the formation of other heterocyclic compounds, depending on the reagents and conditions used.
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3-(3-Methoxyphenyl)piperidine hydrochloride