Chemistry Organic Building Blocks Benzene Compounds 4',5'-diphenyl-1,1':2',1''-terphenyl
Ambeed provide 7 derivatives of 4',5'-diphenyl-1,1':2',1''-terphenyl.
These compounds have the same murcko framework: 4',5'-diphenyl-1,1':2',1''-terphenyl.
Aromatic Substitution: The phenyl rings in 4',5'-diphenyl-1,1':2',1''-terphenyl are susceptible to electrophilic aromatic substitution reactions. For example, you can brominate or nitrate the phenyl rings by treating the compound with bromine or nitric acid, respectively.
Grignard Reaction: If you introduce a reactive functional group elsewhere in the molecule (e.g., a halogen atom), you can perform a Grignard reaction on this compound. This would allow you to add various alkyl or aryl groups to the molecule, creating more complex derivatives.
Reduction: The biphenyl portion of the molecule can be reduced to form a cyclohexyl compound, typically using a reducing agent like lithium aluminum hydride (LiAlH4).
Oxidation: You can oxidize the phenyl rings to form benzoic acid derivatives using strong oxidizing agents like potassium permanganate (KMnO4).
Cross-Coupling Reactions: 4',5'-diphenyl-1,1':2',1''-terphenyl can participate in cross-coupling reactions such as Suzuki-Miyaura or Heck reactions, especially when you introduce suitable leaving groups or functional groups in the molecule.
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[1,1:2,1-Terphenyl]-4,4-dicarboxaldehyde, 4,5-bis(4-formylphenyl)-
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1,2,4,5-Tetrakis(4-carboxyphenyl)benzene
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4',5'-Bis(4-aminophenyl)-[1,1':2',1''-terphenyl]-4,4''-diamine
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4',5'-Bis(4-aminophenyl)-3',6'-dimethyl-[1,1':2',1''-terphenyl]-4,4''-diamine
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4',5'-Bis(4-formylphenyl)-3',6'-dimethyl-[1,1':2',1''-terphenyl]-4,4''-dicarbaldehyde
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4',5'-Bis(4-carboxyphenyl)-3',6'-dimethyl-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid
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3',6'-Dibromo-4',5'-bis(4-carboxyphenyl)-[1,1':2',1''-terphenyl]-4,4''-dicarboxylic acid