Chemistry Heterocyclic Building Blocks Pyridines 4,5,6,7-tetrahydrothieno[2,3-c]pyridine
Ambeed provide 10 derivatives of 4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
These compounds have the same murcko framework: 4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
Aromatic substitution reactions: Depending on the substituents on the ring, it may undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, halogenation, or Friedel-Crafts acylation/alkylation.
Oxidation reactions: The compound can be oxidized under suitable conditions, forming various oxidation products. For example, sulfur atoms in the thieno ring can be oxidized to sulfoxides or sulfones.
Reduction reactions: It can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) to form corresponding saturated derivatives.
Alkylation and acylation reactions: The compound can undergo alkylation or acylation at suitable positions, typically by using alkyl halides or acyl chlorides in the presence of a base or Lewis acid catalyst.
Condensation reactions: It may participate in condensation reactions with other compounds containing nucleophilic or electrophilic functional groups. For instance, it can undergo reactions with amines to form imines or enamines.
Ring-opening reactions: Depending on the conditions, it might undergo ring-opening reactions, particularly if the ring contains strained bonds or reactive functional groups.
Heterocyclic reactions: The compound's heterocyclic nature may make it susceptible to reactions typical of heterocyclic compounds, such as reactions involving the nitrogen and sulfur atoms in the ring.
Photochemical reactions: Some compounds with aromatic or conjugated structures can undergo photochemical reactions when exposed to light of appropriate wavelengths.
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tert-Butyl 4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
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Ethyl 6-Boc-2-amino-4,7-dihydro-5H-thieno[2,3-c]pyridine-3-carboxylate
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tert-Butyl 2-amino-3-carbamoyl-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
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4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride
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6-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
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Methyl 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
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tert-Butyl 2-formyl-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
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Ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
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2-Amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide