Chemistry Heterocyclic Building Blocks Pyridines 4,6-dichloropyridin-3-amine
Ambeed provide 4 derivatives of 4,6-dichloropyridin-3-amine.
These compounds have the same murcko framework: 4,6-dichloropyridin-3-amineNucleophilic substitution: The amine group can undergo nucleophilic substitution reactions with electrophiles, such as alkyl halides or acyl halides, to form substituted products.
Acylation: The amine group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Reductive amination: The amine group can participate in reductive amination reactions with carbonyl compounds, such as aldehydes or ketones, in the presence of reducing agents to form secondary or tertiary amines.
Electrophilic aromatic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions with electrophiles, such as nitration, halogenation, sulfonation, or Friedel-Crafts acylation/alkylation.
Reduction of chlorides: The chlorides can be reduced to corresponding hydrocarbons or substituted with other functional groups under appropriate conditions.
Cross-coupling reactions: The amino group or chlorides can participate in cross-coupling reactions such as Suzuki, Heck, or Stille reactions to form biaryl or heteroaryl compounds.
Heterocyclization: The compound can undergo heterocyclization reactions to form fused or spiro heterocycles under suitable conditions.
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