Chemistry Organic Building Blocks Bromides 2-bromo-4-fluorobenzonitrile
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—C≡N,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Amination: Benzonitrile can be aminated using various reagents to introduce 【amine|https://www.ambeed.com/amines.html】 functional groups.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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