Chemistry Heterocyclic Building Blocks Triazoles 4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole
Aromatic Substitution: The naphthalene ring in the compound is aromatic, so it can undergo electrophilic aromatic substitution reactions. For example, you can react it with electrophilic reagents like nitration (adding a nitro group), halogenation (adding a halogen atom), or Friedel-Crafts acylation/alkylation (adding an acyl or alkyl group).
Nucleophilic Substitution: The 1,2,4-triazole ring contains a nitrogen atom, which can undergo nucleophilic substitution reactions. For instance, you can react it with electrophiles to replace one of the substituents on the triazole ring.
Reduction: If the compound contains any reducible functional groups (e.g., nitro groups), it can undergo reduction reactions to convert them to amino or hydroxyl groups.
Oxidation: If the compound contains any easily oxidizable groups (e.g., alcohols), it can undergo oxidation reactions.
Heterocyclization: The triazole ring itself is a five-membered heterocycle. It can participate in reactions that involve its nitrogen atoms, such as reactions that form fused heterocyclic compounds.
Alkylation: If the compound contains easily alkylatable groups (e.g., an amino group), it can undergo alkylation reactions to add alkyl groups.
Esterification/Amidation: If the compound contains carboxylic acid or amine groups, it can undergo esterification or amidation reactions to form esters or amides, respectively.
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Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
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5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol
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Ethyl 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
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Methyl 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate
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Methyl 2-((5-amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate