Chemistry Heterocyclic Building Blocks Pyridines 4-(benzyloxy)pyridine
Ambeed provide 8 derivatives of 4-(benzyloxy)pyridine.
These compounds have the same murcko framework: 4-(benzyloxy)pyridine.
Electrophilic Aromatic Substitution: The pyridine ring in 4-(benzyloxy)pyridine can undergo electrophilic aromatic substitution reactions. For example, you can perform reactions like Friedel-Crafts acylation or alkylation to introduce substituents on the aromatic ring.
Hydrogenation: The double bond in the benzyloxy group can undergo hydrogenation reactions in the presence of a hydrogen source and a suitable catalyst.
Oxidation: The benzyloxy group can be oxidized to the corresponding benzoic acid or other oxidation products under appropriate conditions.
Reduction: The pyridine ring can undergo reduction reactions, leading to the formation of saturated piperidine derivatives when using reducing agents like hydrogen and a catalyst.
Esterification: 4-(Benzyloxy)pyridine can react with acid chlorides or anhydrides to form esters of the pyridine ring.
Grignard Reactions: 4-(Benzyloxy)pyridine can react with Grignard reagents to form new carbon-carbon bonds and introduce various substituents.
Alkyne Reactions: If there is a triple bond in the molecule, it can participate in reactions such as alkyne addition reactions to form new carbon-carbon bonds.
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Methyl 4-(benzyloxy)-6-(hydroxymethyl)picolinate
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4-(Benzyloxy)pyridine-2-carboxylic acid
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Methyl 4-(benzyloxy)-6-(chloromethyl)picolinate