Chemistry Heterocyclic Building Blocks Pyrimidines 4-(piperazin-1-yl)pyrimidine
Ambeed provide 13 derivatives of 4-(piperazin-1-yl)pyrimidine.
These compounds have the same murcko framework: 4-(piperazin-1-yl)pyrimidine.
Acylation: You can acylate the piperazine nitrogen atoms or the pyrimidine nitrogen atoms with acylating agents like acyl chlorides or anhydrides.
Alkylation: You can alkylate the nitrogen atoms of the piperazine ring or the pyrimidine ring using alkylating agents like alkyl halides.
Nucleophilic Substitution: The nitrogen atoms in both the piperazine and pyrimidine rings can act as nucleophiles in substitution reactions with appropriate electrophiles.
Oxidation: The pyrimidine ring can undergo oxidation reactions under the right conditions, leading to the formation of various oxidation products.
Reduction: The pyrimidine ring can undergo reduction reactions, especially if you have a suitable reducing agent.
Condensation Reactions: You can use 4-(piperazin-1-yl)pyrimidine as a starting material for various condensation reactions with other compounds, such as in the synthesis of more complex heterocyclic compounds.
Metal-Catalyzed Reactions: Transition metal catalysts can be used to facilitate various reactions involving 4-(piperazin-1-yl)pyrimidine, such as cross-coupling reactions or other metal-catalyzed transformations.
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tert-Butyl 4-(pyrimidin-4-yl)piperazine-1-carboxylate
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1-Boc-4-(6-Chloro-5-nitro-4-pyrimidinyl)piperazine
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tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
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6-(4-Methylpiperazin-1-yl)pyrimidin-4-amine
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4-(Piperazin-1-yl)pyrimidine dihydrochloride
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tert-Butyl 4-(6-aminopyrimidin-4-yl)piperazine-1-carboxylate
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2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
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tert-Butyl 4-(2,6-dichloropyrimidin-4-yl)piperazine-1-carboxylate
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2-[4-(6-Amino-2-methylpyrimidin-4-yl)piperazin-1-yl]ethanol
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2-Methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
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4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride
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2-(tert-Butyl)-4-(piperazin-1-yl)-6-(trifluoromethyl)pyrimidine