Chemistry Heterocyclic Building Blocks Piperidines 4-(piperidin-1-yl)pyrimidine
Ambeed provide 9 derivatives of 4-(piperidin-1-yl)pyrimidine.
These compounds have the same murcko framework: 4-(piperidin-1-yl)pyrimidine.
Alkylation: The piperidine nitrogen atom can also be alkylated by using alkyl halides or alkylating agents. This reaction can be carried out in the presence of a base like sodium hydride or potassium carbonate.
Nucleophilic Substitution: The pyrimidine ring, being an aromatic system, can undergo nucleophilic substitution reactions. For example, you can replace one of the hydrogen atoms on the pyrimidine ring with a nucleophilic group.
Oxidation: The compound can undergo oxidation reactions under suitable conditions to introduce oxygen-containing functional groups.
Reduction: Conversely, you can reduce the compound by introducing hydrogen atoms or removing functional groups.
Heterocycle Formation: Depending on the reagents and conditions, 4-(piperidin-1-yl)pyrimidine can participate in reactions to form other heterocycles or fused-ring systems.
Cross-coupling Reactions: If the compound contains suitable functional groups, it can participate in cross-coupling reactions, such as Suzuki, Heck, or Stille couplings, to form biaryl or other complex structures.
Ring Opening: The piperidine ring can undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched structures.
Hydrolysis: The compound can undergo hydrolysis reactions in the presence of water or aqueous acids or bases to break chemical bonds.
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1-(6-Methoxypyrimidin-4-yl)piperidine-4-carboxylic acid
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1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid
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1-(2-Methylpyrimidin-4-yl)piperidin-4-amine
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4-Chloro-6-(piperidin-1-yl)pyrimidin-5-amine
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2-Chloro-5-fluoro-4-(piperidin-1-yl)pyrimidine
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2-Amino-4-piperidino-6-methylpyrimidine