Chemistry Heterocyclic Building Blocks Morpholines 4-(pyrazin-2-yl)morpholine
Ambeed provide 5 derivatives of 4-(pyrazin-2-yl)morpholine.
These compounds have the same murcko framework: 4-(pyrazin-2-yl)morpholine.
Substitution Reactions: The morpholine ring in the compound is susceptible to nucleophilic substitution reactions. For example, it can react with alkyl halides or acyl chlorides to replace one or more hydrogen atoms on the morpholine ring with the substituents.
Amination Reactions: 4-(Pyrazin-2-yl)morpholine can undergo amination reactions, where an amine group is introduced at different positions within the molecule. This can be achieved by using appropriate amine sources and catalysts.
Oxidation Reactions: The pyrazine ring can undergo various oxidation reactions to convert it into different functional groups. For instance, it can be oxidized to form pyrazine-2,3-dicarboxylic acid or other related compounds.
Reduction Reactions: The pyrazine ring can also undergo reduction reactions to form compounds with saturated rings, such as piperazine derivatives.
Cyclization Reactions: Depending on the reaction conditions, 4-(pyrazin-2-yl)morpholine can potentially undergo cyclization reactions to form fused-ring structures.
Cross-Coupling Reactions: It can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to form biaryl or related compounds when appropriate coupling partners are used.
Alkylation Reactions: Alkylation reactions can be used to attach alkyl groups to the pyrazine or morpholine rings.
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5-Bromo-3-morpholinopyrazin-2-amine
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6-(4-Morpholinyl)pyrazine-2-carboxylic acid