Chemistry Heterocyclic Building Blocks Pyridines 4-(pyridin-2-yl)morpholine
Ambeed provide 21 derivatives of 4-(pyridin-2-yl)morpholine.
These compounds have the same murcko framework: 4-(pyridin-2-yl)morpholine.
Nucleophilic Substitution: The nitrogen atom in the morpholine ring can act as a nucleophile and undergo substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated morpholines.
Acylation: The nitrogen in the morpholine ring can react with acyl chlorides or anhydrides to form amides. This is known as acylation, and the product would be a 4-(pyridin-2-yl)morpholine amide.
Alkylation: 4-(pyridin-2-yl)morpholine can undergo alkylation reactions with alkyl halides or alkyl sulfonates to introduce alkyl groups onto the nitrogen in the morpholine ring.
Oxidation: The pyridine ring can undergo oxidation reactions. For example, it can be oxidized to the corresponding pyridine N-oxide using reagents like hydrogen peroxide.
Reduction: If there are reducible functional groups present in the molecule, 4-(pyridin-2-yl)morpholine can be reduced using appropriate reducing agents.
Ring Opening: The morpholine ring can be opened under acidic or basic conditions, leading to the formation of compounds with open-chain structures.
Condensation Reactions: It can participate in condensation reactions, especially with carbonyl compounds, to form products like Mannich bases.
Heterocyclic Chemistry: The pyridine ring can participate in various heterocyclic chemistry reactions, including reactions involving its nitrogen and carbon atoms.
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2,6-Dimethyl-4-(5-nitropyridin-2-yl)morpholine
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4-(5-Bromo-3-chloropyridin-2-yl)morpholine
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6-Morpholinonicotinoyl chloride hydrochloride
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2-Morpholinoisonicotinic acid hydrochloride