Chemistry Heterocyclic Building Blocks Pyrimidines 4-(pyridin-3-yl)pyrimidine
Ambeed provide 5 derivatives of 4-(pyridin-3-yl)pyrimidine.
These compounds have the same murcko framework: 4-(pyridin-3-yl)pyrimidine.
Alkylation: The compound can undergo alkylation reactions with alkyl halides or alkyl sulfonates in the presence of a strong base (e.g., sodium hydride) to form N-alkylated derivatives.
Suzuki-Miyaura Coupling: If there are suitable substituents on the pyridine or pyrimidine rings, 4-(pyridin-3-yl)pyrimidine can participate in Suzuki-Miyaura coupling reactions with aryl or vinyl boronic acids to form biaryl or bivinyl compounds.
Heterocycle Formation: Depending on the reaction conditions, 4-(pyridin-3-yl)pyrimidine can participate in heterocyclization reactions to form fused heterocyclic compounds.
Reductive Reactions: It can undergo various reductive reactions, such as reduction of the pyrimidine ring or the pyridine ring, using appropriate reducing agents.
Oxidation: Oxidation of 4-(pyridin-3-yl)pyrimidine can lead to the formation of various oxidized derivatives.
Substitution Reactions: It can undergo substitution reactions at the pyridine or pyrimidine ring, depending on the electrophilic or nucleophilic nature of the reagents.
Functional Group Transformations: Various functional group transformations, such as halogenation, nitration, or sulfonation, can be performed on 4-(pyridin-3-yl)pyrimidine to introduce different substituents.
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2-Chloro-4-(pyridin-3-yl)pyrimidine
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6-(Pyridin-3-yl)pyrimidin-4-amine
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2-Chloro-4-(2-fluoropyridin-3-yl)pyrimidine