Chemistry Heterocyclic Building Blocks Pyrimidines 4-(pyrimidin-4-yl)morpholine
Ambeed provide 13 derivatives of 4-(pyrimidin-4-yl)morpholine.
These compounds have the same murcko framework: 4-(pyrimidin-4-yl)morpholine.
Nucleophilic Substitution: The morpholine nitrogen can act as a nucleophile and undergo substitution reactions with electrophiles. For example, it can react with alkyl halides, forming N-alkylmorpholine derivatives.
Alkylation: The pyrimidine nitrogen can undergo alkylation reactions with alkyl halides, leading to the introduction of alkyl groups on the pyrimidine ring.
Reductive Amination: 4-(Pyrimidin-4-yl)morpholine can undergo reductive amination reactions with aldehydes or ketones in the presence of reducing agents like sodium cyanoborohydride to form secondary amines.
Cyclization Reactions: Depending on the reaction conditions and reagents, 4-(pyrimidin-4-yl)morpholine can participate in various cyclization reactions to form heterocyclic compounds.
Hydrolysis: The morpholine ring can undergo hydrolysis under acidic or basic conditions, leading to the cleavage of the morpholine ring and the formation of various products.
Cross-Coupling Reactions: The pyrimidine nitrogen can participate in cross-coupling reactions with various coupling partners to form biaryl or heteroaryl compounds.
Redox Reactions: 4-(Pyrimidin-4-yl)morpholine may undergo redox reactions under appropriate conditions, such as oxidation or reduction reactions.
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4-(6-Chloro-2-trifluoromethylpyrimidin-4-yl)morpholine
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5-Bromo-2-chloro-4-morpholinopyrimidine
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4-(2-Chloropyrimidin-4-yl)morpholine
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2-Chloro-4-morpholinopyrimidine-5-carbaldehyde
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2-Amino-4-morpholin-4-yl-pyrimidine
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4-(6-Hydrazinylpyrimidin-4-yl)morpholine
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4-(2-Chloro-6-methylpyrimidin-4-yl)morpholine
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4-(6-Chloro-2-methylpyrimidin-4-yl)morpholine