Chemistry Heterocyclic Building Blocks Pyridines 4-(trifluoromethyl)pyridine
Ambeed provide 14 derivatives of 4-(trifluoromethyl)pyridine.
These compounds have the same murcko framework: 4-(trifluoromethyl)pyridineNucleophilic Substitution: The trifluoromethyl group can be substituted by a nucleophile, leading to the formation of a new compound.
Electrophilic Substitution: The electron-rich pyridine ring can undergo electrophilic substitution reactions, where an electrophile replaces one of the hydrogen atoms attached to the ring.
Metalation: The pyridine ring can undergo metalation reactions, where a metal atom or ion replaces one of the hydrogen atoms attached to the ring.
Redox Reactions: 4-(trifluoromethyl)pyridine can participate in redox reactions, either as an oxidizing agent or a reducing agent, depending on the reaction conditions.
Addition Reactions: Depending on the reaction conditions and the nature of the reagents involved, addition reactions can occur, leading to the addition of functional groups to the pyridine ring or the trifluoromethyl group.
Elimination Reactions: Under appropriate conditions, elimination reactions can occur, leading to the removal of certain functional groups or atoms from the molecule.
Catalytic Reactions: 4-(trifluoromethyl)pyridine can participate in various catalytic reactions, either as a catalyst or as a substrate.
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4-(Trifluoromethyl)pyridine-2-carboxylic acid methyl ester
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2-(Chloromethyl)-4-(trifluoromethyl)pyridine
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(S)-1-(4-(Trifluoromethyl)pyridin-2-yl)ethan-1-amine
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2-Methyl-4-(trifluoromethyl)pyridine hydrochloride