Chemistry Heterocyclic Building Blocks Pyrimidines 4-(trifluoromethyl)pyrimidine
Ambeed provide 12 derivatives of 4-(trifluoromethyl)pyrimidine.
These compounds have the same murcko framework: 4-(trifluoromethyl)pyrimidineArylation Reactions: The presence of the trifluoromethyl group makes the compound useful in transition metal-catalyzed arylations. For example, it might participate in reactions like Suzuki coupling or Stille coupling to form arylated products.
Nucleophilic Aromatic Substitution: The pyrimidine ring is aromatic, and under certain conditions, it might undergo nucleophilic aromatic substitution reactions, particularly at positions that are not hindered by the trifluoromethyl group.
Reduction Reactions: The trifluoromethyl group contains electron-withdrawing fluorine atoms, and under specific conditions, it might undergo reduction reactions.
Halogenation: The pyrimidine ring might undergo halogenation reactions, especially if there are activating or directing groups present.
N-Substitution Reactions: The nitrogen atoms in the pyrimidine ring can potentially undergo substitution reactions, for example, with alkyl halides or acyl chlorides.
Condensation Reactions: The compound might participate in condensation reactions, especially if there are reactive hydrogen atoms adjacent to the pyrimidine ring or in the trifluoromethyl group.
Cyclization Reactions: Depending on the reaction conditions and the presence of appropriate functional groups, the compound might participate in cyclization reactions.
Metalation Reactions: The compound might undergo metalation reactions, where a metal reagent replaces a hydrogen atom on the molecule.
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5-Bromo-4-(trifluoromethyl)pyrimidine
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4-(Trifluoromethyl)pyrimidine-5-carbonitrile
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5-Chloro-2-(methylthio)-4-(trifluoromethyl)pyrimidine
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2-(Ethylsulfonyl)-4-(trifluoromethyl)pyrimidine
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2-Methyl-4-(trifluoromethyl)pyrimidine-5-carboxylic acid
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4-(Trifluoromethyl)pyrimidine-5-carboxylic acid
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Methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate
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4-(Trifluoromethyl)pyrimidine-5-carboxamide