Chemistry Heterocyclic Building Blocks Morpholines 4-benzylmorpholin-3-one
Ambeed provide 6 derivatives of 4-benzylmorpholin-3-one.
These compounds have the same murcko framework: 4-benzylmorpholin-3-one.
Reduction: The ketone group in 4-benzylmorpholin-3-one can be reduced to an alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Acylation: The ketone group can undergo acylation reactions to form various derivatives. For example, it can react with acyl chlorides or anhydrides to form ketals or esters.
Nucleophilic Addition: The ketone carbon can undergo nucleophilic addition reactions, particularly if a strong nucleophile is present. This can lead to the formation of a new carbon-oxygen bond.
Grignard Reaction: 4-benzylmorpholin-3-one can react with a Grignard reagent (organomagnesium compound) to form a tertiary alcohol derivative.
Substitution Reactions: The benzyl group in 4-benzylmorpholin-3-one can potentially undergo substitution reactions, depending on the reaction conditions and the nature of the substituent.
Cyclization Reactions: Given the presence of the morpholine ring, intramolecular cyclization reactions might occur under appropriate conditions, leading to the formation of cyclic products.
Oxidation: The benzyl group can be oxidized to a carboxylic acid using strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
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(R)-4-Benzyl-5-oxomorpholine-3-carboxylic acid
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(S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid
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2-Hydroxy-4-(phenylmethyl)-3-morpholinone
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Methyl (S)-4-Benzyl-5-oxomorpholine-3-carboxylate
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Methyl 4-benzyl-5-oxomorpholine-3-carboxylate