3-methylthiophene-Thiophenes| Ambeed

Chemistry Organic Building Blocks Iodides 4-bromo-2-fluoro-1-iodobenzene

4-bromo-2-fluoro-1-iodobenzene

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —I,—F,—Br).

Metalation Reactions: Iodobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.

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