Chemistry
Organic Building Blocks
Bromides
4-bromo-3-(trifluoromethyl)aniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CF3,—NH2).
Suzuki-Miyaura Coupling: Bromobenzene can participate in cross-coupling reactions with organoboron compounds in the presence of a palladium catalyst, resulting in the formation of biaryl compounds.
Friedel-Crafts Acylation/Alkylation: The (trifluoromethyl)benzene can undergo Friedel-Crafts acylation or alkylation reactions, in which an acyl or alkyl group is added to the benzene ring. These reactions are catalyzed by Lewis acids and result in the formation of new carbon-carbon bonds.
Schiff Base Formation: Aniline can react with 【aldehydes|https://www.ambeed.com/aldehydes.html】 and 【ketones|https://www.ambeed.com/ketones.html】 to form Schiff bases, which are important intermediates in organic synthesis.
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4-Bromo-2-fluoro-5-(trifluoromethyl)aniline
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4-Bromo-3,5-bis(trifluoromethyl)aniline
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4-Bromo-2-nitro-5-(trifluoromethyl)aniline
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4-Bromo-5-(trifluoromethyl)benzene-1,2-diamine