Chemistry Heterocyclic Building Blocks Pyridines 4-bromo-3-methylpyridine
Ambeed provide 5 derivatives of 4-bromo-3-methylpyridine.
These compounds have the same murcko framework: 4-bromo-3-methylpyridineNucleophilic Substitution: The bromine atom in 4-bromo-3-methylpyridine can be substituted by a nucleophile. This could involve reactions with nucleophiles like amines or thiols, leading to the formation of substituted products.
Metalation: The pyridine ring can undergo metalation reactions, where a metal (such as lithium or magnesium) inserts itself into the ring, usually at the 2 or 4 position, displacing the bromine atom.
Reduction: The bromine atom in 4-bromo-3-methylpyridine can be reduced to a bromide ion or completely removed, depending on the reducing agent used. This could result in the formation of 3-methylpyridine or even further reduced products.
Cross-Coupling Reactions: 4-bromo-3-methylpyridine can participate in cross-coupling reactions, such as Suzuki, Heck, or Sonogashira reactions, where the bromine atom serves as a reactive site for coupling with various other organic or organometallic compounds.
Functional Group Transformations: The bromine atom or the methyl group in 4-bromo-3-methylpyridine can undergo various functional group transformations, such as oxidation, substitution, or elimination reactions, leading to the formation of diverse products.
Arylation: 4-bromo-3-methylpyridine can undergo arylation reactions where it reacts with aryl halides or aryl metal reagents in the presence of a suitable catalyst, leading to the introduction of aryl groups onto the pyridine ring.
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Methyl 2-(4-bromo-5-methylpyridin-2-yl)acetate