Chemistry Heterocyclic Building Blocks Pyridines 4-bromopyridine
Nucleophilic Substitution: The bromine atom in 4-bromopyridine can be substituted by various nucleophiles such as amines, thiols, and hydroxide ions. This can lead to the formation of substituted pyridine derivatives.
Metalation: 4-bromopyridine can react with strong bases to undergo metalation, where a metal ion replaces the hydrogen atom on the pyridine ring. This can be useful in further synthetic transformations.
Cross-Coupling Reactions: 4-bromopyridine can undergo cross-coupling reactions, particularly with palladium or nickel catalysts. This allows for the formation of carbon-carbon or carbon-heteroatom bonds at the 4-position of the pyridine ring.
Reductive Elimination: Under appropriate conditions, the bromine atom in 4-bromopyridine can undergo reductive elimination, leading to the formation of a double bond. This reaction is often employed in organic synthesis to construct complex molecules.
Electrophilic Aromatic Substitution: The pyridine ring in 4-bromopyridine can undergo electrophilic aromatic substitution reactions, where an electrophile replaces a hydrogen atom on the ring. This can lead to various substituted pyridine derivatives.
Oxidation and Reduction Reactions: 4-bromopyridine can undergo oxidation or reduction reactions depending on the conditions and reagents used. For example, it can be oxidized to form pyridine-4-carboxylic acid, or reduced to form tetrahydropyridine derivatives.
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2-Amino-4-bromopyridin-3-ol hydrobromide
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4-Bromo-2-(2-fluoropropan-2-yl)pyridine
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tert-Butyl ((4-bromopyridin-2-yl)methyl)carbamate
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4-Bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine
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tert-Butyl 2-(4-bromopyridin-2-yl)acetate
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4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
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N-((4-Bromopyridin-2-yl)methyl)acetamide