Chemistry Heterocyclic Building Blocks Pyridines 4-chloro-2,6-dimethylpyridine
Nucleophilic substitution: The chlorine atom can undergo nucleophilic substitution reactions with nucleophiles such as amines or thiols, leading to the formation of corresponding substituted products.
Electrophilic aromatic substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions with electrophiles, such as Friedel-Crafts acylation or alkylation, resulting in the introduction of new substituents onto the ring.
Oxidation reactions: The methyl groups on the pyridine ring can undergo oxidation under appropriate conditions, leading to the formation of various oxidation products.
Reduction reactions: Similarly, the chloro and methyl substituents can undergo reduction reactions under suitable conditions, leading to the formation of reduced products.
Metalation reactions: The pyridine ring can be metalated at the 2 or 6 position under certain conditions, providing an avenue for further functionalization or coordination chemistry.
Cross-coupling reactions: The pyridine can undergo cross-coupling reactions with suitable partners, such as Suzuki, Heck, or Sonogashira reactions, allowing for the synthesis of more complex molecules.
Halogenation reactions: The methyl groups or the pyridine ring itself can undergo halogenation reactions under appropriate conditions, leading to the incorporation of halogen atoms into the molecule.
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