Chemistry Heterocyclic Building Blocks Pyrimidines 4-chloro-2-(methylthio)pyrimidine
Ambeed provide 29 derivatives of 4-chloro-2-(methylthio)pyrimidine.
These compounds have the same murcko framework: 4-chloro-2-(methylthio)pyrimidine Nucleophilic Substitution (SN2): The chlorine atom in the compound is a good leaving group, and the methylthio group can act as a nucleophile, participating in SN2 reactions with suitable electrophiles. This could include reactions with alkyl halides or other electrophiles.
Nucleophilic Aromatic Substitution: Pyrimidines can undergo nucleophilic aromatic substitution reactions. The nucleophile could attack the carbon adjacent to the chlorine atom, leading to substitution of the chlorine with the nucleophile.
Substitution at the Methylthio Group: The methylthio group can undergo various substitution reactions. For example, it could be replaced by a nucleophile in the presence of a suitable leaving group.
Cross-Coupling Reactions: The compound might be involved in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Stille coupling, where the carbon-chlorine bond could be replaced by a different substituent.
Base-Catalyzed Hydrolysis: The compound might undergo base-catalyzed hydrolysis, especially if there are susceptible functional groups. This could result in the cleavage of bonds involving the chlorine or methylthio group.
Oxidation: The methylthio group is potentially oxidizable, and the compound might undergo oxidation reactions under certain conditions.
Alkylation: The nitrogen atoms in the pyrimidine ring could potentially undergo alkylation reactions with suitable alkylating agents.
Reduction: The chlorine atom or other reducible groups might undergo reduction reactions, typically in the presence of reducing agents.
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4-Chloro-6-(methoxymethyl)-2-(methylthio)pyrimidine
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5-Bromo-6-chloro-2-(methylthio)pyrimidin-4-amine
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4-Chloro-6-methoxy-2-(methylthio)pyrimidine
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4-Chloro-6-methoxy-2-(methylthio)-5-nitropyrimidine
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Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
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Ethyl 2-(4-chloro-2-(methylthio)pyrimidin-5-yl)acetate
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1-(4-Chloro-2-(methylthio)pyrimidin-5-yl)ethanone
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Ethyl 2-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-methylpropanoate
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Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate
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4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde
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4-Chloro-2-(methylsulphanyl)pyrimidine-5-carbonitrile
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4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine
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4-Chloro-5-methoxy-2-(methylthio)pyrimidine
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4-Chloro-5-methyl-2-(methylthio)pyrimidine
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4-Chloro-6-hydrazinyl-2-(methylthio)pyrimidine
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5-Bromo-4-chloro-6-methyl-2-(methylthio)pyrimidine
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6-Chloro-N-isopropyl-2-(methylthio)pyrimidin-4-amine
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6-Chloro-N-methyl-2-(methylthio)pyrimidin-4-amine
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(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol
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4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid
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4-Chloro-6-methyl-2-(methylthio)pyrimidine
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4-Chloro-2-(methylthio)-5-(trifluoromethyl)pyrimidine
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6-Chloro-N,N-dimethyl-2-(methylthio)pyrimidin-4-amine
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4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile