Chemistry Heterocyclic Building Blocks Pyridines 4-chloro-2-methoxypyridine
Ambeed provide 6 derivatives of 4-chloro-2-methoxypyridine.
These compounds have the same murcko framework: 4-chloro-2-methoxypyridineNucleophilic substitution: The chlorine atom (Cl) can be replaced by a nucleophile, such as an amine or an alcohol, to form a new compound.
Electrophilic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile substitutes for a hydrogen atom on the ring.
Cross-coupling reactions: 4-chloro-2-methoxypyridine can participate in cross-coupling reactions with various coupling partners, such as organometallic reagents or aryl halides, to form biaryl compounds.
Reduction: The chlorine atom or the methoxy group can be reduced to different functional groups, such as alkyl groups or hydrogens, using reducing agents.
Oxidation: The pyridine ring or the methoxy group can be oxidized to introduce functional groups such as alcohols, ketones, or carboxylic acids.
Alkylation or acylation: The pyridine nitrogen can undergo alkylation or acylation reactions with alkyl or acyl halides, respectively, to introduce alkyl or acyl groups onto the nitrogen atom.
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