Chemistry Heterocyclic Building Blocks Pyridines 4-chloro-3-methylpyridine
Ambeed provide 7 derivatives of 4-chloro-3-methylpyridine.
These compounds have the same murcko framework: 4-chloro-3-methylpyridineSubstitution Reactions: The chlorine atom in the compound can undergo substitution reactions with nucleophiles, such as in SN1 or SN2 reactions. For example, it can be replaced by another nucleophile, leading to the formation of a different substituted pyridine derivative.
Acylation Reactions: The compound can undergo acylation reactions, where the methyl or chlorine group acts as a nucleophile to attack an acyl group, leading to the formation of an amide or ester derivative.
Metalation Reactions: The compound can undergo metalation reactions, where a metal such as lithium or magnesium replaces the hydrogen atom in the methyl group, leading to the formation of an organometallic compound.
Oxidation/Reduction Reactions: The compound can undergo oxidation or reduction reactions, depending on the conditions and reagents used. For example, it can be oxidized to form a pyridine N-oxide or reduced to form a dihydropyridine derivative.
Cyclization Reactions: Under certain conditions, the compound can undergo cyclization reactions to form cyclic compounds, such as heterocyclic compounds or fused ring systems.
Nucleophilic Aromatic Substitution (SNAr): The compound can undergo SNAr reactions where a nucleophile replaces the leaving group (chlorine) on the aromatic ring.
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Methyl 4-chloro-5-methylpicolinate
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Methyl 4-chloro-3-methylpicolinate
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4-Chloro-5-methyl-2-(trifluoromethyl)pyridine