Chemistry Heterocyclic Building Blocks Pyrimidines 4-chloro-5-fluoro-2-methylpyrimidine
Ambeed provide 5 derivatives of 4-chloro-5-fluoro-2-methylpyrimidine.
These compounds have the same murcko framework: pyrimidine
Substitution Reactions: The chlorine (Cl) and fluorine (F) atoms are potential leaving groups, and the methyl group (CH3) may also undergo substitution reactions with appropriate reagents.
Nucleophilic Reactions: The nitrogen atoms in the pyrimidine ring can potentially undergo nucleophilic reactions with suitable electrophiles.
Acylation or Alkylation Reactions: The nitrogen atoms may act as nucleophiles in acylation or alkylation reactions.
Cross-coupling Reactions: The halogen substituents (chlorine and fluorine) can participate in various cross-coupling reactions, such as Suzuki coupling or Stille coupling.
Oxidation or Reduction Reactions: The compound may undergo oxidation or reduction reactions depending on the reaction conditions.
Ring Closure Reactions: The compound may participate in ring-closure reactions, particularly if the reaction conditions favor such transformations.
Heterocycle Synthesis: The pyrimidine ring itself can participate in various heterocycle synthesis reactions.
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6-Chloro-5-fluoro-2-methylpyrimidin-4-ol
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4,6-Dichloro-5-fluoro-2-methylpyrimidine
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6-Chloro-5-fluoro-2-methylpyrimidin-4-amine
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4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine