Chemistry Heterocyclic Building Blocks Pyridines 4-chloronicotinic acid
Ambeed provide 4 derivatives of 4-chloronicotinic acid.
These compounds have the same murcko framework: 4-chloronicotinic acidSubstitution Reactions: The chlorine atom in the 4-position of the pyridine ring can undergo substitution reactions. For instance, it can be substituted with other nucleophiles or electrophiles under appropriate conditions. This could include reactions such as nucleophilic aromatic substitution or electrophilic aromatic substitution.
Esterification: The carboxylic acid group (-COOH) can undergo esterification reactions with alcohols in the presence of an acid catalyst to form esters.
Amide Formation: The carboxylic acid group can react with amines to form amide compounds.
Oxidation: The compound can be oxidized under certain conditions, typically requiring strong oxidizing agents.
Reduction: It can be reduced under appropriate conditions, typically requiring reducing agents.
Acid-Base Reactions: It can undergo acid-base reactions, where the carboxylic acid group can be deprotonated by strong bases.
Metal Complexation: It can form complexes with metal ions, particularly transition metal ions.
Polymerization: Under certain conditions, it may participate in polymerization reactions, especially in the presence of suitable catalysts.
Halogenation: It may undergo further halogenation reactions under specific conditions.
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4-Chloro-2-(trifluoromethyl)nicotinic acid
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4-Chloro-6-(trifluoromethyl)nicotinic acid
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4-Chloropyridine-2,3-dicarboxylic acid