Chemistry Heterocyclic Building Blocks Pyridines 4-chloropyridin-2-amine
Ambeed provide 6 derivatives of 4-chloropyridin-2-amine.
These compounds have the same murcko framework: 4-chloropyridin-2-amineSubstitution reactions: The chlorine atom in the 4-position of the pyridine ring can undergo substitution reactions with various nucleophiles, such as amines, alcohols, thiols, or cyanide ions. These reactions can lead to the synthesis of substituted pyridines.
Acylation reactions: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to yield N-acyl derivatives of 4-chloropyridin-2-amine.
Reductive amination: The amino group can undergo reductive amination reactions with carbonyl compounds in the presence of reducing agents to form secondary or tertiary amines.
Condensation reactions: The amino group can participate in condensation reactions with carbonyl compounds, such as aldehydes or ketones, to form imines or Schiff bases.
Oxidation reactions: Both the amino group and the chloro substituent can undergo oxidation reactions under appropriate conditions, leading to the formation of corresponding oxidation products.
Cross-coupling reactions: The amino group or the chloro substituent can participate in cross-coupling reactions, such as Suzuki, Heck, or Sonogashira reactions, to form biaryl or heteroaryl compounds.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
4-Chloro-6-(trifluoromethyl)pyridin-2-amine