Chemistry Heterocyclic Building Blocks Pyridines 4-chloropyridine
Ambeed provide 31 derivatives of 4-chloropyridine.
These compounds have the same murcko framework: 4-chloropyridineSubstitution Reactions: The chlorine atom can undergo substitution reactions with various nucleophiles, such as amines or organometallic reagents, leading to the formation of different substituted products.
Nucleophilic Aromatic Substitution (SNAr): The electron-deficient nature of the pyridine ring makes it susceptible to nucleophilic aromatic substitution reactions, where the chlorine atom can be replaced by a nucleophile.
Metalation: 4-chloropyridine can react with strong bases, such as alkali metals or organolithium reagents, to form metalated intermediates. These intermediates can further react with electrophiles to introduce various functional groups.
Heterocyclic Chemistry: The pyridine ring in 4-chloropyridine can participate in various heterocyclic transformations, such as ring-closure reactions with suitable reagents to form fused or spirocyclic heterocycles.
Reduction: The chlorine atom can be reduced to a hydrogen atom using reducing agents, leading to the formation of 4-aminopyridine.
Oxidation: Conversely, 4-chloropyridine can undergo oxidation reactions, converting the chlorine atom to other functional groups, such as alcohols, aldehydes, or carboxylic acids.
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4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide
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Methyl 4-chloro-3-fluoropicolinate
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(R)-2-Amino-2-(4-chloropyridin-2-yl)ethanol dihydrochloride
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2-Chloro-1-(4-chloropyridin-2-yl)ethanone
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Di-tert-butyl 4-chloropyridine-2,6-dicarboxylate
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1-(4-Chloropyridin-2-yl)-2,2,2-trifluoroethanamine
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1-(4-Chloropyridin-2-yl)-2-methylpropan-1-amine
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1-(4-Chloropyridin-2-yl)propan-1-one
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1-(4-Chloropyridin-2-yl)-2,2,2-trifluoroethyl trifluoromethanesulfonate