Chemistry
Heterocyclic Building Blocks
Pyrimidines
4-chloropyrimidin-2-amine
Nucleophilic Substitution: The amine group can act as a nucleophile and participate in nucleophilic substitution reactions. For example, it can react with alkyl halides or other electrophiles to form substituted amines.
Amidation Reactions: The amine group can react with acyl chlorides, acid anhydrides , or carboxylic acids to form amide bonds.
Condensation Reactions: The amine group can participate in condensation reactions with carbonyl compounds to form imines or Schiff bases.
Alkylation Reactions: The amino group may undergo alkylation reactions, where it reacts with alkylating agents to form alkylated amines.
Substitution Reactions: The chlorine atom on the pyrimidine ring can undergo substitution reactions, where it can be replaced by other nucleophiles under appropriate conditions.
Reductive Amination: The amine group can participate in reductive amination reactions with carbonyl compounds, leading to the formation of secondary or tertiary amines.
Heterocycle Formation: The compound can be involved in reactions that lead to the formation of other heterocyclic compounds, especially given the presence of the pyrimidine ring.
Oxidation Reactions: The amino group can be oxidized under certain conditions to form nitro groups or other oxidized derivatives.
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5-Bromo-4-chloro-6-methylpyrimidin-2-amine
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Ethyl 2-amino-4-chloropyrimidine-5-carboxylate
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4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine
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2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine
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6-Chloro-N4,N4-dimethylpyrimidine-2,4-diamine