Chemistry Heterocyclic Building Blocks Pyridines 4-cyclopropylpyridine
Ambeed provide 7 derivatives of 4-cyclopropylpyridine.
These compounds have the same murcko framework: 4-cyclopropylpyridine.
Arylation or Alkylation: 4-cyclopropylpyridine can undergo electrophilic aromatic substitution reactions, where the cyclopropylpyridine ring can be arylated or alkylated at various positions. This can be achieved using suitable electrophilic reagents and catalysts.
Nucleophilic Substitution: The cyclopropyl group is susceptible to nucleophilic substitution reactions. For example, you can replace the cyclopropyl group with other nucleophiles in the presence of appropriate reagents.
Reduction: The pyridine ring can be reduced to piperidine using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: The cyclopropyl group can be oxidized to a carbonyl group (e.g., a ketone) under oxidative conditions.
Grignard Reactions: 4-cyclopropylpyridine can react with Grignard reagents to form various products, depending on the specific reagents and conditions.
Acylation: It can undergo acylation reactions to introduce acyl groups onto the pyridine ring.
Heterocycle Formation: It can participate in heterocycle formation reactions with other reagents that contain reactive functional groups.
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2-(Pyridin-4-yl)cyclopropanecarboxylic acid
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1-(Pyridin-4-yl)cyclopropanecarboxylic acid
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Methyl 1-(pyridin-4-yl)cyclopropanecarboxylate
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trans-2-(pyridin-4-yl)cyclopropanecarboxylic acid
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1-(2-Bromopyridin-4-yl)cyclopropanecarbonitrile