Chemistry Heterocyclic Building Blocks Pyrimidines 4-ethoxypyrimidine
Ambeed provide 6 derivatives of 4-ethoxypyrimidine.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Substitution Reactions: 4-Ethoxy Pyrimidine could undergo nucleophilic substitution reactions, where a nucleophile replaces the ethoxy group. This can happen, for example, with nucleophiles like amines, thiolates, or alkoxides.
Acid-Base Reactions: The nitrogen atoms in the pyrimidine ring are basic and can react with acids to form salts. Conversely, the ethoxy group could potentially be deprotonated under basic conditions.
Electrophilic Substitution Reactions: The pyrimidine ring can also undergo electrophilic substitution reactions, where an electrophile replaces one of the hydrogen atoms on the ring. This could happen with reactions involving electrophilic reagents.
Ether Cleavage: The ether linkage in the ethoxy group may be susceptible to cleavage under certain conditions. Acidic or basic conditions may lead to the cleavage of the ether bond.
Alkylation and Acylation: The pyrimidines nitrogen atoms can potentially undergo alkylation or acylation reactions with appropriate alkyl or acyl halides.
Reductive Reactions: 4-Ethoxy Pyrimidine could undergo reductive reactions with suitable reducing agents, leading to the reduction of functional groups.
Metalation: The pyrimidine ring can be metalated under certain conditions, forming a metal complex.
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