Chemistry Heterocyclic Building Blocks Indoles 4-fluoro-1H-indole

4-fluoro-1H-indole

Ambeed provide 24 derivatives of 4-fluoro-1H-indole.

These compounds have the same murcko framework: indole

Nucleophilic Substitution: The fluorine atom in the 4-position of the indole ring can undergo nucleophilic substitution reactions, where a nucleophile replaces the fluorine. Common nucleophiles include amines, Thiols, and organometallic reagents.
Electrophilic Substitution: The indole ring is electron-rich and can undergo electrophilic aromatic substitution reactions. For example, reaction with electrophiles such as acyl chlorides, bromine, or nitration agents can lead to the introduction of substituents at various positions on the indole ring.
Metalation Reactions: Metalation with Organolithium Reagents: 4-fluoro-1H-indole can react with organolithium reagents to form lithiated intermediates. This intermediate can then undergo further reactions with various electrophiles.
Reduction: The fluorine atom can be reduced to other functional groups, such as a hydrogen atom, using reducing agents like lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Oxidation: The compound can undergo oxidation reactions to introduce oxygen-containing functional groups. Common oxidizing agents include potassium permanganate (KMnO4) or chromic acid.
Suzuki Coupling or Heck Reaction: 4-fluoro-1H-indole can participate in cross-coupling reactions with suitable partners, such as aryl or vinyl halides, in the presence of palladium catalysts.

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  • 90%
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Conditions to empty

Framework+−

(1-(tert-butoxycarbonyl)-1H-indol-2-yl)boronic acid (1H-indol-2-yl)boronic acid (1H-indol-2-yl)methanol (3aS,7aS)-octahydro-1H-indole (9H-fluoren-9-yl)methyl (2-(1H-indol-3-yl)ethyl)carbamate 1,2,3,4-tetrahydrocyclopenta[b]indole 1,2-dimethyl-1H-indole 1-(1H-indol-1-yl)ethan-1-one 1-(1H-indol-3-yl)-N,N-dimethylmethanamine 1-(1H-indol-3-yl)ethan-1-one 1-(phenylsulfonyl)-1H-indole 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 1-benzyl-1H-indole 1-ethyl-1H-indole 1-methyl-1H-indole 1-methyl-1H-indole-2-carboxylic acid 1-methyl-1H-indole-3-carbaldehyde 1-methyl-1H-pyrrolo[2,3-b]pyridine 1-phenyl-1H-indole 1H-indol-3-ol 1H-indol-3-yl acetate 1H-indol-4-amine 1H-indol-4-ol 1H-indol-5-ol 1H-indol-6-amine 1H-indol-6-ol 1H-indol-7-amine 1H-indole-2-carbaldehyde 1H-indole-2-carbonitrile 1H-indole-3-carbaldehyde 1H-indole-3-carbonitrile 1H-indole-3-carboxylic acid 1H-indole-4-carboxylic acid 1H-indole-5-carbonitrile 1H-indole-5-carboxylic acid 1H-indole-6-carbonitrile 1H-indole-6-carboxylic acid 1H-indole-7-carbonitrile 1H-indole-7-carboxylic acid 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 2,3-dimethyl-1H-indole 2-(1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole 2-(1H-indol-1-yl)acetic acid 2-(1H-indol-3-yl)acetic acid 2-(1H-indol-3-yl)ethan-1-amine 2-(1H-indol-3-yl)ethan-1-ol 2-(2-methyl-1H-indol-3-yl)acetic acid 2-(4-fluorophenyl)-1H-indole 2-methyl-1H-indole-3-carbaldehyde 2-methyl-1H-pyrrolo[2,3-b]pyridine 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(1H-indol-3-yl)propanoic acid 3-(piperidin-4-yl)-1H-indole 3-iodo-1H-pyrrolo[2,3-b]pyridine 3-methyl-1H-indole 3H-indole 4-bromo-1H-indole 4-chloro-1H-indole 4-fluoro-1H-indole 4-fluoro-1H-pyrrolo[2,3-b]pyridine 4-fluoroindoline-2,3-dione 4-methoxy-1H-indole 4-methyl-1H-indole 4-nitro-1H-indole 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 5-(benzyloxy)-1H-indole 5-bromo-1-methyl-1H-indole 5-chloro-1H-indole 5-chloro-1H-indole-2-carboxylic acid 5-chloro-1H-pyrrolo[2,3-b]pyridine 5-fluoro-1H-indole 5-fluoro-1H-pyrrolo[2,3-b]pyridine 5-fluoroindolin-2-one 5-methoxy-1H-indole 5-methoxy-2-methyl-1H-indole 5-methyl-1H-indole 5-nitro-1H-indole 6-(trifluoromethyl)-1H-indole 6-bromo-1-methyl-1H-indole 6-bromo-1H-indole 6-bromo-1H-pyrrolo[2,3-b]pyridine 6-chloro-1H-indole 6-chloro-1H-pyrrolo[2,3-b]pyridine 6-fluoro-1H-indole 6-methoxy-1H-indole 6-methyl-1H-indole 6-methyl-1H-pyrrolo[2,3-b]pyridine 6-nitro-1H-indole 7-bromo-1H-indole 7-bromoindoline-2,3-dione 7-chloro-1H-indole 7-fluoro-1H-indole 7-fluoro-1H-indole-2-carboxylic acid 7-methoxy-1H-indole 7-methyl-1H-indole 7-nitro-1H-indole 9H-pyrido[3,4-b]indole benzo[cd]indol-2(1H)-one ethyl 1H-indole-3-carboxylate ethyl 5-chloro-1H-indole-2-carboxylate ethyl 5-fluoro-1H-indole-2-carboxylate ethyl 6-chloro-1H-indole-2-carboxylate ethyl 7-chloro-1H-indole-2-carboxylate methyl 1H-indole-3-carboxylate methyl 1H-indole-4-carboxylate methyl 1H-indole-5-carboxylate methyl 1H-indole-6-carboxylate methyl 1H-indole-7-carboxylate methyl 2-(1H-indol-3-yl)acetate N-(2-(1H-indol-3-yl)ethyl)acetamide spiro[indoline-3,4'-piperidin]-2-one tert-butyl 1H-indole-1-carboxylate tert-butyl 1H-pyrrolo[2,3-b]pyridine-1-carboxylate tert-butyl 2-(1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate tert-butyl 3-bromo-1H-indole-1-carboxylate tert-butyl 3-iodo-1H-indole-1-carboxylate tert-butyl 5-methoxy-1H-indole-1-carboxylate tryptophan

By Key Group+−

aminoindole azaindole benzoindole benzyloxyindole biindolinylidene boronate-indole bromo-indole-carboxylate bromo-indole-carboxylic acid bromo-methyl-indole bromoindole chlorindole-carboxylic acid chloro-indole-carboxylate chloro-methyl indole chloroindole cyanoindole dihydroindolo dimethyl-indole dioxaborolan-indole dioxaborolan-indole-carboxylate fluorindole-carboxylic acid fluoro-indole-carboxylate fluoroindole fluoromethyl-indole formyl-indole-carboxylate formylindole hydroxyindole hydroxyisoindoline hydroxymethy-indole-carboxylate indol-amine indol-methanamine indol-methanol indol-one indole-boronic acid/ester indole-carbonitrile indole-ethanol indole-ethylamine indole-hydrochloride indole-hydroxyl indolecarboxylate indolecarboxylic iodo-indole isoindole methanoisoindole methoxy-indole-carboxylate methoxy-methyl-indole methoxyindole methyl-indole-carboxylic-acid methyl-nitro-indole methylindole nitro-indole-carboxylate nitroindole phenyl-indole piperidine-indole pyridinoindole pyrimido-indole trifluoromethyl-indole

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Aromatic Heterocycles Benzofurans Indolines Other Aromatic Heterocycles Piperazines Piperidines Pyrazoles Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines

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Alcohols Aldehydes Alkenyls Amides Amines Aryls Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydroxylamines Iodides Ketones Nitriles Nitroes Organoboron Phenols Sulfamides Sulfides Trifluoromethyls

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    By Configuration+−

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