Chemistry Heterocyclic Building Blocks Pyrimidines 4-fluoropyrimidine
Ambeed provide 8 derivatives of 4-fluoropyrimidine.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Substitution: Fluorine is often a good leaving group, so nucleophilic substitution reactions may occur. For instance, a nucleophile could replace the fluorine atom, leading to the formation of a new compound.
Aromatic Substitution: If the fluorine is attached to an aromatic ring (as in the case of pyrimidines), aromatic substitution reactions may occur.
Base-Catalyzed Hydrolysis: The pyrimidine ring is susceptible to base-catalyzed hydrolysis, leading to the cleavage of the ring and the formation of different products.
Metalation Reactions: Pyrimidines can undergo metalation reactions, where a metal replaces a hydrogen atom on the ring. This can be useful for further reactions involving the metal-substituted pyrimidines.
Functional Group Reactions: Depending on the presence of other functional groups on the pyrimidines ring or any substituents, various reactions such as oxidation, reduction, or addition reactions may occur.
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6-Fluoro-5-methylpyrimidin-4-amine