Chemistry Heterocyclic Building Blocks Pyridines 4-iodopyridine
Ambeed provide 17 derivatives of 4-iodopyridine.
These compounds have the same murcko framework: 4-iodopyridineSubstitution Reactions: The iodine atom in 4-iodopyridine can undergo substitution reactions with nucleophiles. For instance, it can undergo nucleophilic substitution reactions with strong nucleophiles such as amines or thiols to replace the iodine atom with the nucleophile, leading to the formation of substituted pyridine derivatives.
Metalation Reactions: 4-Iodopyridine can be used as a substrate in metalation reactions, where the iodine atom serves as a directing group for metal insertion into the pyridine ring. This can lead to the formation of organometallic complexes, which can further participate in various organic transformations.
Cross-Coupling Reactions: 4-Iodopyridine can undergo cross-coupling reactions with suitable partners such as aryl or vinyl halides in the presence of a transition metal catalyst. For example, Suzuki-Miyaura coupling with arylboronic acids, Heck reaction with alkenes, or Stille coupling with organotin compounds.
Reduction Reactions: The iodine atom in 4-iodopyridine can be reduced to form the corresponding pyridine derivative. This reduction can be achieved using reducing agents such as sodium borohydride or lithium aluminum hydride.
Functional Group Interconversions: Various functional groups present in 4-iodopyridine can undergo transformation reactions to introduce different functional groups. For example, the iodine atom can be replaced with other functional groups through substitution reactions, or the nitrogen atom in the pyridine ring can undergo functionalization reactions.
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(R)-2-((5-Chloro-4-iodopyridin-2-yl)amino)propan-1-ol
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5-Chloro-4-iodo-2-(trifluoromethyl)pyridine
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4-Iodo-6-(trifluoromethyl)pyridin-3-amine