Chemistry Organic Building Blocks Fluorinated Building Blocks 3-((tert-butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—CH2CH(CH2COOH)NHCOOC(CH3)3).
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
Esterification: The 【carboxylic acid|https://www.ambeed.com/carboxylic-acids.html】 group can undergo esterification reactions with 【alcohols|https://www.ambeed.com/alcohols.html】 or 【acid chlorides|https://www.ambeed.com/acyl-chlorides.html】 in the presence of a suitable catalyst, such as DCC (dicyclohexylcarbodiimide) or SOCl2(thionyl chloride), to form 【esters|https://www.ambeed.com/esters.html】.
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(S)-3-((tert-Butoxycarbonyl)amino)-4-(2,4-difluorophenyl)butanoic acid
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(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
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(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid
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(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4-difluorophenyl)butanoic acid
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(R)-b-(Boc-amino)-2,5-difluorobenzenebutanoic acid
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(S)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid
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Boc-(S)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid