Chemistry Heterocyclic Building Blocks Pyridines 4-methyl-3-nitropyridine
Ambeed provide 8 derivatives of 4-methyl-3-nitropyridine.
These compounds have the same murcko framework: 4-methyl-3-nitropyridineElectrophilic aromatic substitution: The nitro group is electron-withdrawing, making the pyridine ring more reactive towards electrophilic aromatic substitution reactions. For instance, it can undergo nitration, halogenation, sulfonation, etc.
Reduction: The nitro group can be reduced to an amino group under suitable conditions, such as using reducing agents like hydrogen gas over a catalyst, or with metal/acid systems like iron and hydrochloric acid.
Substitution reactions on the methyl group: The methyl group can undergo substitution reactions, such as nucleophilic substitution or oxidation if conditions permit.
Ring-opening reactions: Depending on the reaction conditions, ring-opening reactions can occur, leading to the formation of different compounds.
Condensation reactions: The nitrogen atom in the pyridine ring can participate in condensation reactions with appropriate reagents, forming various heterocyclic compounds.
Metal complex formation: The nitrogen atom can act as a ligand and form complexes with various metal ions.
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N,N,4-Trimethyl-5-nitropyridin-2-amine
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4-Methyl-3-nitropyridine hydrochloride