Chemistry Heterocyclic Building Blocks Pyridines 4-methylpyridine
Ambeed provide 24 derivatives of 4-methylpyridine.
These compounds have the same murcko framework: 4-methylpyridineNucleophilic substitution: The nitrogen lone pair in the pyridine ring can act as a nucleophile, participating in substitution reactions with electrophiles.
Acid-base reactions: Like pyridine, 4-methylpyridine is a weak base. It can undergo protonation reactions with acids to form the corresponding conjugate acid.
Alkylation and acylation: The nitrogen atom can be alkylated or acylated under appropriate conditions, leading to the introduction of alkyl or acyl groups at the nitrogen position.
Oxidation and reduction reactions: The nitrogen atom can be oxidized or reduced depending on the reaction conditions. For example, it can be oxidized to form N-oxide or reduced to form a dihydropyridine.
Metal complexation: The nitrogen lone pair can coordinate with metal ions to form metal complexes, leading to various coordination chemistry reactions.
Substitution at the methyl group: The methyl group at the 4-position can undergo various substitution reactions, such as electrophilic aromatic substitution.
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Ethyl 2-methyl-2-(4-methylpyridin-2-yl)propanoate
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tert-Butyl ((4-methylpyridin-2-yl)methyl)carbamate
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Methyl 6-(chloromethyl)-4-methylpicolinate
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4-Methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
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4-Methyl-2-pyridyl Trifluoromethanesulfonate
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2-(Chloromethyl)-4-methylpyridine hydrochloride