Chemistry Heterocyclic Building Blocks Pyrimidines 4-methylpyrimidin-2-amine
Ambeed provide 9 derivatives of 4-methylpyrimidin-2-amine.
These compounds have the same murcko framework: 4-methylpyrimidin-2-amineNucleophilic Substitution Reactions: The amino group in 4-methylpyrimidin-2-amine can act as a nucleophile and participate in substitution reactions. For example, it can react with alkyl halides or other electrophiles to form substituted amines.
Acylation Reactions: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Alkylation Reactions: The amino group may also undergo alkylation reactions with alkyl halides or alkylating agents.
Condensation Reactions: The amino group can participate in condensation reactions, such as the formation of imines or imidazoles, depending on the reaction conditions and the nature of the reactants.
Oxidation and Reduction Reactions: Depending on the conditions, the amine group may be subject to oxidation to form nitro groups or reduction to form secondary or tertiary amines.
Cyclization Reactions: The compound's structure may allow for intramolecular cyclization reactions, leading to the formation of cyclic products.
Substitution Reactions on the Pyrimidine Ring: Depending on the reaction conditions, the methyl group on the pyrimidine ring may undergo substitution reactions.
Metalation Reactions: The amino group can react with certain metal reagents to form metal-amido complexes.
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2-Amino-5-bromo-4,6-dimethylpyrimidine
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2-Amino-4-methylpyrimidine-5-carboxylic acid
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2-Amino-4-methylpyrimidine-5-carbonitrile
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Ethyl 2-amino-4-methylpyrimidine-5-carboxylate