Chemistry Heterocyclic Building Blocks Pyridines 4-phenoxypyridine
Ambeed provide 7 derivatives of 4-phenoxypyridine.
These compounds have the same murcko framework: 4-phenoxypyridine.
Electrophilic Aromatic Substitution (EAS): 4-Phenoxypyridine can undergo EAS reactions in its pyridine ring, similar to other aromatic compounds. For example, it can react with electrophiles (e.g., acyl chlorides) to introduce substituents at various positions on the pyridine ring.
Grignard Reactions: Grignard reagents (alkyl or aryl magnesium halides) can react with 4-phenoxypyridine, leading to the formation of substituted derivatives. This is a common way to introduce alkyl or aryl groups onto the pyridine ring.
Oxidation and Reduction: 4-Phenoxypyridine can be subject to oxidation or reduction reactions, depending on the reaction conditions. Oxidation can convert it into compounds like 4-hydroxypyridine, while reduction can reduce the pyridine ring or the phenyl group.
Cross-Coupling Reactions: Palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, can be employed to form C-C bonds between 4-phenoxypyridine and other organic compounds.
Diazotization: The amino group can be diazotized to form a diazonium salt, which can then undergo various reactions like Sandmeyer reactions to produce aryl halides, hydroxyl compounds, or other derivatives.
Esterification and Amidation: 4-Phenoxypyridine can undergo esterification or amidation reactions, allowing for the introduction of ester or amide groups onto the compound.
Acylation: The pyridine ring can be acylated using acyl chlorides or anhydrides to introduce acyl groups onto the molecule.
Alkylation and Arylation: The phenyl group can be alkylated or arylated using appropriate reagents and conditions.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
click to sign in and save
4-(Pyridin-4-yloxy)benzene-1-sulfonyl chloride hydrochloride
click to sign in and save
4-(4-Formamidophenoxy)-N-methylpicolinamide