Chemistry Heterocyclic Building Blocks Pyridines 4-phenyl-1,4-dihydropyridine
Ambeed provide 10 derivatives of 4-phenyl-1,4-dihydropyridine.
These compounds have the same murcko framework: 4-phenyl-1,4-dihydropyridine.
Hydrogenation: Reduction of the double bond in the dihydropyridine ring to form the corresponding piperidine derivative.
Oxidation: Oxidation of the dihydropyridine ring to convert it back to the pyridine ring. This can be achieved by using various oxidizing agents.
Alkylation: Introduction of alkyl groups (methyl, ethyl, etc.) at various positions on the dihydropyridine ring using appropriate alkylating agents.
Acylation: Introduction of acyl groups (acyl chlorides, anhydrides, etc.) at various positions on the dihydropyridine ring to form acyl derivatives.
Reductive Amination: Conversion of the compound into primary, secondary, or tertiary amines by reacting with suitable aminating agents in the presence of reducing agents.
Ring Opening: Ring-opening reactions to break the dihydropyridine ring and form open-chain compounds, often under acidic or basic conditions.
Halogenation: Halogenation of the phenyl ring or the dihydropyridine ring to introduce halogen substituents.
Catalytic Hydrogenation: Reduction of the dihydropyridine ring using catalytic hydrogenation with a metal catalyst like palladium or platinum.
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Dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid