5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-Pyrimidines| Ambeed

Chemistry Heterocyclic Building Blocks Pyrimidines 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Ambeed provide 7 derivatives of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine.

These compounds have the same murcko framework: 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine.

Aromatic Substitution: If there are suitable electron-withdrawing or electron-donating groups on the pyrimidine ring, it can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, or halogenation.
Nucleophilic Substitution: If there are electrophilic centers on the molecule, it can undergo nucleophilic substitution reactions with appropriate nucleophiles.
Reduction: Reduction reactions can be performed to reduce any unsaturated bonds within the molecule. For example, catalytic hydrogenation can be used to reduce double bonds.
Alkylation and Acylation: If there are suitable functional groups like amino or hydroxyl groups, they can undergo alkylation or acylation reactions, respectively.
Cyclization: Depending on the structure, it may be possible to intramolecularly cyclize the compound to form other heterocyclic rings or fused ring systems.
Oxidation: Oxidation reactions can be performed to introduce oxygen atoms into the molecule or to convert functional groups from lower oxidation states to higher ones.
Substitution at the Pyridine Nitrogen: If the pyridine nitrogen is accessible and there are appropriate leaving groups, substitution reactions at this position can occur.